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. 2015 Mar 16;36(5):585–597. doi: 10.1093/carcin/bgv021

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Figure 5. — Effect of Snail2 constitutive deletion in hematopoietic progenitors during skin chemical carcinogenesis. (A) Tumor burden (lesions/mouse) showing the differences between Snail2 ^+/+_BMSnail2 ^−/− and Snail2 ^+/+_BMSnail2 ^+/+ mice after DMBA/TPA treatment; n = 7 mice per experimental group. *P ≤ 0.05. (B) Tumor size comparison between Snail2 ^+/+_BMSnail2 ^+/+ and Snail2 ^+/+_BMSnail2 ^−/− lesions. (C) Flow cytometry analysis of CD11b⁺/Gr-1⁺ population in blood, BM and tumors in Snail2 ^+/+_BMSnail2 ^+/+ and Snail2 ^+/+_BMSnail2 ^−/− mice after DMBA/TPA treatment. (D) Flow cytometry analysis of CD4+, CD8+, CD19+ and F4/80+ cell populations of Snail2 ^+/+_BMSnail2 ^+/+ and Snail2 ^+/+_BMSnail2 ^−/− tumors. (C) and (D) n = 4 and 5 for Snail2 ^+/+_BMSnail2 ^+/+ and Snail2 ^+/+_BMSnail2 ^−/− mice, respectively. t-Test, *P ≤ 0.05, **0.001 < P < 0.005, ***P ≤ 0.001.