Wheat germ agglutinin, TUNEL, Masson’s trichrome and Ki67 stainings were performed in left ventricular sections from CT and R-cKO mice at baseline and after 4 weeks of pressure overload. Representative pictures are shown (B, D, F, H). Cell size (A), percentage of TUNEL-positive cells (C), percentage of fibrosis (E) and percentage of Ki67-positive cells (G) were measured. N=3–5. All data are expressed as mean ± SEM and as fold vs. CT when specified. * p<0.05. Scale bar= 100 µm.