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. Author manuscript; available in PMC: 2016 Jun 15.
Published in final edited form as: Mol Cell Endocrinol. 2015 Mar 25;408:90–98. doi: 10.1016/j.mce.2015.03.014

Figure 1. Transduceosome and metabolon complexes.

Figure 1

The transduceosome consists of cytosolic and OMM proteins as indicated by grey margin. The metabolon, a protein complex that consists of OMM, IMS and IMM proteins, is indicated in red margin. VDAC1 and TSPO are members of both the transduceosome and metabolon. CYP11A1 enzyme, located at the mitochondrial matrix side of IMM, and ATAD3, present at the contact sites of IMM and OMM, are members unique to the metabolon complex. The transduceosome mediates the import of cholesterol from cytosolic sources to mitochondria, while the metabolon serves to direct the cholesterol molecule to CYP11A1 where it can be converted to pregnenolone.