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. Author manuscript; available in PMC: 2016 May 15.
Published in final edited form as: J Immunol. 2015 Apr 15;194(10):4951–4962. doi: 10.4049/jimmunol.1402431

Figure 5. DUSP3 deficiency promotes tolerance to septic shock.

Figure 5

(A–B) Bacterial colonies count in the peritoneum (A) and in the peripheral blood (B) of DUSP3+/+ and DUSP3−/− mice at the indicated time points after CLP. All mice used for the 24h time point received one dose of antibiotics (25 mg/kg ceftrioxane and 15 mg/kg metronidazole) eight hours after surgery. Each circle represents a single mouse. Open circles represent DUSP3+/+ and dark circles represent DUSP3−/− mice. Horizontal lines represent mean ± SEM. (C–D) Plasma nitrate (C) and Urea (D) levels of DUSP3+/+ and DUSP3−/− mice at basal levels and at the indicated time points after CLP surgery or after LPS i.p administration. (n=5 mice per group/time point). Results are presented as mean ± SEM. * p<0.05, **<0,001***P<0.001.