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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Trends Microbiol. 2015 Jan 29;23(5):283–288. doi: 10.1016/j.tim.2015.01.002

Figure 1. Differences between models of virion transport and egress.

Figure 1

Two models of anterograde viral transport are depicted; Separate and Married. In the Separate model, the putative state of viral protein assemblies are shown for Rhabdoviridae, either RV or VSV. In this case, viral nucleocapsid assemblies transport in association with glycoprotein containing vesicles. At the point of egress, glycoproteins in the axonal membrane would direct nucleocapsid assembly into an infectious virion. In the Married model the assembly and egress of the alpha herpes virus PRV is depicted. In this circumstance, virion assembly occurs in the neuronal soma and undergoes axonal transport inside a transport vesicle. At sites of egress, this transport vesicle fuses with axonal membranes, releasing a fully infectious herpes virion into the extracellular space.