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. Author manuscript; available in PMC: 2016 May 15.
Published in final edited form as: J Immunol. 2015 Apr 13;194(10):4676–4687. doi: 10.4049/jimmunol.1402870

Figure 9.

Figure 9

The suppressive effect of rHDL on BMDCs activation is dependent on ABCA1 and SR-BI. BMDCs from WT, ABCG1-/-, ABCA1-/- and SR-BI-/- mice (n=4-6/group) were stimulated with LPS (0.5 μg/mL) and treated with 4 μM rHDL for 12 h. (A) Levels of IL-6, IL-12 p70, TNF-α, IL-23, IL-8 and IL-10 in culture supernatants of stimulated BMDCs. Percentages of cytokine secretion are shown for LPS-stimulated BMDCs after treatment with rHDL, normalized against untreated LPS-stimulated BMDCs of the same genotype. (B) Representative western blot images of pSTAT3, total STAT3 and actin are shown for each genotype. (C) Levels of pSTAT3 and actin were quantified by densitometry and the pSTAT3/actin ratio was calculated. In panels A and C results are expressed as mean ± SEM; data are combined of at least two independent experiments. *p<0.05, **p<0.01, ***p<0.001; ns; not significantly different.