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. Author manuscript; available in PMC: 2016 Jun 3.
Published in final edited form as: Brain Res. 2015 Mar 24;1609:21–30. doi: 10.1016/j.brainres.2015.03.032

Figure 1.

Figure 1

Systemic treatment of animals with celastrol protects RGCs from ONC injury. RGC densities in vehicle- and celastrol-treated animals. Celastrol (1 mg/kg) or vehicle was administered daily by i.p injection. RGCs were immunolabeled with antibodies against Rbpms and counted in inferior, superior, temporal and nasal retinal quadrants. A. Images represent inferior retina 3 mm from the center of the optic nerve head. B. Two weeks after ONC, the average density of remaining RGCs in the retinas of animals treated with celastrol was 1332±152 cells/mm2 compared to 381±58 RGCs/mm2 in the DMSO/ONC group (n=6 per group; *P=0.004).