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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Surgery. 2015 Feb 27;157(5):888–898. doi: 10.1016/j.surg.2015.01.006

Figure 6. Improved survival in a peritoneal carcinomatosis model.

Figure 6

HP-1 cells (1×106) were injected into the peritoneal cavity of Syrian hamsters on day 0. A single intraperitoneal dose of adenovirus (2×1011 vp) was administered seven days thereafter (indicated by arrow) or the animals were left untreated. Survival rate was significantly improved with the IFN-expressing virus (RGD-ΔE3-ADP-ham-IFN) compared to the untreated control (p=0.001). The wild type virus (RGD-Wt) also demonstrated a survival improvement, but it was not statistically significant. Results are shown as a proportion of surviving animals according to the Kaplan-Meier method. There were 8 animals in the untreated control group and 7 animals in the groups that received virus.