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. Author manuscript; available in PMC: 2016 Jun 15.
Published in final edited form as: Mol Cell Endocrinol. 2014 Dec 8;408:165–177. doi: 10.1016/j.mce.2014.12.003

Fig. 2.

Fig. 2

Changes in histology and gene expression associated with GDX-induced adrenocortical neoplasia. (A,B) Neoplastic cells in the adrenal cortex of a B6D2F1 female mouse that underwent prepubertal GDX 4 mo earlier. Immunoperoxidase staining for GATA4 highlights small type A cells (arrowheads) and large type B cells (arrows). Bars = 100 µm. (C) Expression of gonadal-like differentiation markers in the adrenal glands of gonadectomized vs. intact female DBA/2J mice. Whole adrenal glands from 4-mo-old gonadectomized or intact virgin female DBA/2J mice were subjected to qRT-PCR analysis. Results are normalized to β-actin mRNA levels (× 102). *P< 0.05.