. Author manuscript; available in PMC: 2015 May 3.

Published in final edited form as: Pharmacogenet Genomics. 2009 Jan;19(1):87–89. doi: 10.1097/FPC.0b013e32830fbde4

Table 1.

The COMT polymorphisms listed in the NCBI SNP database (http://www.ncbi.nlm.nih.gov/SNP).

Amino acid positions (S / MB)	Amino acid residue		Effect on the enzyme functions
Amino acid positions (S / MB)	Wild type	Mutant type	Effect on the enzyme functions
– /9	L	F	Unknown (unpublished)
– / 34	C	S	Unknown (unpublished)
12 / 62	H	H^*	No functional change expected
22 / 72	A	S	Lower catalytic activity and reduced thermostability [33]
23 / 73	Q	Q^*	No functional change expected
42 / 92	V	M	Unknown (unpublished)
52 / 102	A	T	Reduced thermostability [33]
62 / 112	L	L^*	No functional change expected
84 / 134	A	A^*	No functional change expected
86 / 136	L	A	Unknown (unpublished)
96 / 146	A	V	Unknown (unpublished)
108 / 158	V	M	Reduced thermostability [17, 29–32]
149 / 199	P	L	Unknown (unpublished)
153 / 203	L	L^*	No functional change expected

These nucleic acid mutations will not alter the amino acids that are encoded by the altered codons.