Table 1.

A comparison of the fungal Gβ-like proteins.

	Species	Cellular process	Molecular character	GPCR	Gα partner	βγ dimer	Downstream effectors
	S. cerevisiae	Pheromone signaling	Seven-bladed WD repeat predicted for the C-terminal 400 amino acids (structure based on PDB: 2CNX)	Unknown	Gpa1•GDP	No	Catalytic subunit of PI3K
	S. cerevisiae	Glucose to cAMP signaling	Seven kelch repeats forming Gβ-like β-propeller (structure based on residues WGP through FTPN of PDB: 1GOF)	Gpr1	Gpa2•GDP Gpa2•GTP	Yes: Noncanonical Gγ Gpg1	PKA, Ira1, Ira2
	C. neoformans	Glucose to cAMP signaling	Seven-bladed WD repeats predicted based on homology with RACK1 (structure based on chain A from PDB: 1TRJ)	Gpr4	Gpa1	Yes: γ subunits are Gpg1 Gpg2	Smg1
	S. pombe	Pheromone signalling	Seven-bladed WD repeat protein (structure based on PDB: 2CNX)	Mam2, Map3	Gpa1	Unknown	Unknown