Skip to main content
. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Biomaterials. 2015 Apr 16;56:104–113. doi: 10.1016/j.biomaterials.2015.03.043

FIGURE 5.

FIGURE 5

In vivo summary of CRP, ATW and NT MB performance in the imaging of tumors (A and B), blood vessels (C and D), tumor – vessel comparison (E and F), and antibody blocking of CRP MB tumor accumulation (G). Normalized intensities in tumors decreased more slowly with CRP MBs than with ATW and NT MBs (A), indicating that the CRP MBs bound to the tumor more than ATW and NT MBs (B). The blood clearance of CRP MBs was similar to NT MBs, and slower than ATW MBs (C), with half-lives of 2.2, 1.2, and 3.1 min for CRP, ATW, and NT MBs, respectively (D). The normalized intensity difference between the tumor and vessel shows that the target/background signal ratio increased with CRP MBs, but not with ATW or NT MBs (E and F). Antibody injection decreased the normalized intensity difference from 0.58 ± 0.10 to 0.36 ± 0.10 (G). For (A–F), n=4, paired one way ANOVA tests with Tukey’s multiple comparisons correction were performed in Graphpad Prism 6; and for G, n=7, a paired t test was performed in Excel. *, p<0.05; **, p<0.01.