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. Author manuscript; available in PMC: 2015 May 3.
Published in final edited form as: Arthritis Rheumatol. 2015 Apr;67(4):877–886. doi: 10.1002/art.39018

Figure 3.

Figure 3

Radiographic progression in rheumatoid arthritis patients in the Leiden Early Arthritis Clinic cohort per number of risk alleles or amino acids at HLA–DRB1, HLA–B, and HLA–DPB1. The median raw and unmodeled Sharp/van der Heijde scores (SHS) during 7 years of followup of 594 RA patients are shown. The P values obtained by multivariate normal regression analyses comparing the genotypes in relation to radiographic progression were P = 5.33 × 10−5 for the DRB1 shared epitope (SE) alleles, P = 4.94 × 10−5 for Val/Leu at DRB1 position 11, P = 0.044 for Ser at DRB1 position 11, P = 0.62 for Asp at HLA–B position 9, and P = 0.036 for Phe at DPB1 position 9.