Skip to main content
. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Neurobiol Aging. 2015 Jan 3;36(3):1439–1450. doi: 10.1016/j.neurobiolaging.2014.12.029

Fig. 3.

Fig. 3

Misoprostol treatment decreases neuronal death but not bleeding volume in the collagenase-induced ICH model. (A) Fluoro-Jade B (FJB) histological staining in sections collected 3 days after collagenase injection revealed substantial degeneration of neurons and processes in the perihematomal region. Scale bar = 50 µm. Insets represent FJB-positive degenerating neurons at higher magnification. Compared with vehicle-treated mice, misoprostol-treated mice had 60% fewer FJB-positive neurons in the peri-ICH area on day 3 after ICH (n=8 mice/group, **p<0.01, t-test). (B) Misoprostol treatment did not affect collagenase-induced bleeding. The level of hemoglobin content in the homogenate of injured striatum did not differ between misoprostol- and vehicle-treated mice when measured at 24 hours after ICH (n=6 mice/group, p>0.05). All values are means ± SD.