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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Neurobiol Aging. 2015 Jan 3;36(3):1439–1450. doi: 10.1016/j.neurobiolaging.2014.12.029

Fig. 7.

Fig. 7

Misoprostol treatment decreases HMGB1 expression, Src kinase activity, and IL-1β expression in the collagenase-induced ICH model. (A–D) Western blot analysis shows the effects of misoprostol treatment on levels of HMGB1 (A), phosphorylated (P−) and total Src (B), COX-2 (C), and IL-1β (D) in the hemorrhagic hemisphere on day 1 after ICH. β-actin and total Src were used as loading controls. Misoprostol treatment reduced immunoreactivity of HMGB1, phosphorylated Src, and IL-1β, but not COX-2 on day 1 after ICH. O.D., optical density. n=5 mice/group; All values are means ± SD; *p<0.05, **p<0.01, t-test.