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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Neurobiol Aging. 2015 Jan 3;36(3):1439–1450. doi: 10.1016/j.neurobiolaging.2014.12.029

Fig. 9.

Fig. 9

Src kinase inhibition with PP2 is protective in the collagenase-induced ICH model. (A, B) Western blot analysis showed that PP2 treatment reduced the level of phosphorylated (P−) Src, but not HMGB1 protein levels on day 1 after ICH (n=5 mice/group). Src kinase inhibition with PP2 decreased brain water content in the ipsilateral striatum (C) and neurologic deficit score (D) on day 3 after ICH (both n=6 mice/group). (E) Gelatin gel zymography showed that Src kinase inhibition with PP2 reduced the activity of pro-MMP-9 (98 kDa band), but not pro-MMP-2 (72 kDa band), on day 1 after ICH (n=5 mice/group). Std, mouse gelatinase standards. O.D., optical density; Ipsi, ipsilateral; Cont, contralateral. All values are means ± SD; *p<0.05, **p<0.01, t-test.