Table 4.
Significantly up- and downregulated sncRNAs
| a) Downregulated in PDAC | |||||
|---|---|---|---|---|---|
| sRNA | NEV normal | NEV PDAC | Log2 FoldChange | FDR | Previously shown |
| hsa-miR-216b | 57,650.3 | 99.6 | 9.2 | 0.0000000 | [7,8,11] |
| hsa-miR-216a-3p | 3,218.9 | 4.1 | 9.6 | 0.0000000 | [7,8,11] |
| hsa-miR-217 | 86,322.3 | 143.1 | 9.2 | 0.0000000 | [7-9,11] |
| hsa-miR-216a-5p | 35,959.9 | 144.7 | 8.0 | 0.0000000 | [7-9,11] |
| hsa-miR-802 | 3,702.2 | 2.0 | 10.9 | 0.0000000 | - |
| hsa-miR-148a-5p | 4,252.9 | 178.9 | 4.6 | 0.0000000 | [7-9,11] |
| hsa-miR-2114-5p | 88.5 | 0.9 | 6.6 | 0.0000000 | - |
| hsa-miR-375 | 121,790.3 | 11,992.2 | 3.3 | 0.0000001 | [7-9,11] |
| hsa-miR-130b-5p | 890.4 | 95.1 | 3.2 | 0.0000002 | [7-9,11] |
| hsa-miR-148a-3p | 224,094.2 | 25,764.7 | 3.1 | 0.0000005 | [7-9,11] |
| hsa-miR-130b-3p | 3,038.0 | 395.2 | 2.9 | 0.0000008 | [7-9,11] |
| hsa-miR-190b | 436.6 | 19.5 | 4.5 | 0.0000026 | - |
| hsa-miR-2114-3p | 44.7 | 0.3 | 7.0 | 0.0000270 | - |
| hsa-sno-HBII-296B | 1,159.5 | 208.8 | 2.5 | 0.0000525 | - |
| hsa-miR-30c-2-3p | 164.1 | 27.1 | 2.6 | 0.0000657 | [7-12] |
| hsa-miR-219-5p | 219.7 | 36.4 | 2.6 | 0.0000808 | [7] |
| hsa-piR-017061 | 4,818,0 | 951,7 | 2,3 | 0.0001447 | - |
| hsa-miR-30a-3p | 1,350.4 | 275.0 | 2,3 | 0.0001447 | [7-9,12] |
| hsa-miR-29c-3p | 41,297.8 | 8.131.4 | 2,3 | 0.0003007 | [7-9,12] |
| hsa-sno-U104 | 7,726.4 | 1.703.0 | 2,2 | 0.0007282 | - |
| b) Upregulated in PDAC | |||||
| hsa-miR-135b-3p | 1.2 | 80.9 | −6.1 | 0.0000000 | [11,12] |
| hsa-miR-135b-5p | 948.9 | 9,475.0 | −3.3 | 0.0000002 | [11,12] |
| hsa-miR-21-3p | 174.6 | 2,117.3 | −3.6 | 0.0000005 | [7-12] |
| hsa-miR-708-5p | 309.2 | 3,100.3 | −3.3 | 0.0000022 | [7,10] |
| hsa-miR-615-3p | 1.2 | 97.2 | −6.3 | 0.0000024 | [7] |
| hsa-miR-34c-5p | 47.5 | 475.2 | −3.3 | 0.0000048 | [11] |
| hsa-miR-431-5p | 7.0 | 99.7 | −3.8 | 0.0000062 | - |
| hsa-miR-511 | 17.1 | 242.6 | −3.8 | 0.0000079 | - |
| hsa-miR-143-5p | 238.7 | 2,089.8 | −3.1 | 0.0000092 | [7-10,12] |
| hsa-miR-222-3p | 2,263.7 | 17,399.2 | −2.9 | 0.0000131 | [7-12] |
| hsa-miR-34c-3p | 2.7 | 49.7 | −4.2 | 0.0000210 | - |
| hsa-miR-155-5p | 392.4 | 3,458.7 | −3.1 | 0.0000210 | [7-10,12] |
| hsa-miR-24-2-5p | 396.5 | 2,965.3 | −2.9 | 0.0000407 | [9,10,12] |
| hsa-miR-34b-3p | 1.0 | 29.5 | −4.9 | 0.0000681 | [7,9] |
| hsa-miR-708-3p | 24.4 | 188.7 | −3.0 | 0.0001073 | [7,10] |
| hsa-miR-223-5p | 17.4 | 204.8 | −3.6 | 0.0001117 | [7-10,12] |
| hsa-miR-34b-5p | 12.5 | 96.7 | −3.0 | 0.0001145 | [7,9,11] |
| hsa-miR-10a-3p | 101.1 | 643.8 | −2.7 | 0.0001447 | [7-10] |
| hsa-miR-196b-5p | 10.1 | 738.0 | −6.2 | 0.0001832 | [9,11] |
| hsa-miR-2355-3p | 3.8 | 43.2 | −3.5 | 0.0002933 | - |
For the 20 most significantly up- and downregulated sncRNAs the mean normalized expression values (NEV) for each group is provided together with the ratio between normal and PDAC expression in log2 scale (log2FoldChange). In addition, the column “previously shown” indicates if other groups have provided evidence for the deregulation of the RNA before.