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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Trends Neurosci. 2015 Apr 14;38(5):279–294. doi: 10.1016/j.tins.2015.03.003

Figure 1. Stress induced internalization of AMPARs in D1R-expressing medium spiny neurons in the NAc underlies some stress-induced depression-like behavioral changes.

Figure 1

A. Whole-cell recording of evoked excitatory synaptic currents from D1R-expressing MSNs at −70 mV and +40 mV for analysis of AMPAR- and NMDAR-mediated components in slices from control and chronically stressed mice. Chronic stress decreased the AMPAR component, but not the NMDAR component. B,C. Transfection of D1R-expressing cells with a peptide that prevents stress-induced AMPAR internalization prevented the stress-induced loss of sucrose preference (B), but not stress-induced immobility in the forced swim test (C). Modified with permission from Lim et al., 2012 [29].