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Antagonists of HGF and c-Met binding
| Group | Compound | Developmental stage |
References |
|---|---|---|---|
| HGF/c-Met antagonists | NK4 | Preclinical | (57, 58) |
| Uncleavable HGF | Preclinical | (59) | |
| Sema | Preclinical | (60) | |
| Decoy Met | Preclinical | (61) | |
| Recombinant variant Met | Preclinical | (62) | |
| Antibodies against HGF | L2G7 (Galaxy Biotech) | Preclinical | (63) |
| AMG102 (Amgen) | Phase II | (64) | |
| Antibodies against HGF | OA-5D5 (Genentech) | Preclinical | (65) |
| CE-355621 (Pfizer) | Preclinical | (66) | |
| DN30 (Metheresis) | Preclinical | (67) | |
