Skip to main content
. Author manuscript; available in PMC: 2015 Nov 15.
Published in final edited form as: J Immunol. 2015 Apr 6;194(10):4924–4930. doi: 10.4049/jimmunol.1401362

FIG 6. Inhibiting IRF-7 or neutralising CCL7 does not affect histopathology during RV-induced exacerbation of AAD.

FIG 6

BALB/c mice were sensitized and challenged to HDM to induce AAD, then administered with IRF-7 targeting siRNA or CCL7 antibodies and subsequently infected with RV to induce exacerbation of AAD. Mice were sacrificed 24hrs post infection for analyses. Lung histopathology showing representative pulmonary inflammation in 5μm slices of fixed lungs with (A) Carbol’s chromotrope-hematoxylin (CR) stains for peribronchiolar inflammation where each image was originally obtained at 200x magnification and is typical of four mice. (B-C) Total histopathological score evaluated using a semiquantitative scoring system described previously (15). All results are Mean±SEM at 1 dpi (n=4-8 mice per group). ****, p < 0.0001 as compared to nonsense or isotype control group.