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. Author manuscript; available in PMC: 2015 Nov 15.
Published in final edited form as: J Immunol. 2015 Apr 3;194(10):4705–4716. doi: 10.4049/jimmunol.1402979

Figure 6.

Figure 6

Quantitative proteomics (LC-MS/MS) confirms increased ECM peptide abundance in Cyp2j4−/− nephritic kidneys. (A) Heat map showing up-regulated (left panel) and down-regulated (right panel) peptides in Cyp2j4−/− specifically under NTN (day 10) conditions (i. differentially expressed between Cyp2j4−/−-basal and -NTN but not differentially expressed between WT and WT-NTN, ii. differentially expressed between Cyp2j4−/−-NTN and WT-NTN). (B) Normalised abundance of unique peptides for Col1a1, Fn1 and Lum in WT and Cyp2j4−/− rat kidneys in basal (untreated) and under NTN conditions. Note that these 3 genes’ expression is up-regulated in Cyp2j4−/− BMDMs (Figure 3A).