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. Author manuscript; available in PMC: 2015 Jun 19.
Published in final edited form as: Leuk Lymphoma. 2014 Nov 3;56(5):1392–1397. doi: 10.3109/10428194.2014.953148

Table I. Baseline characteristics of the study population.

AML patients without CNS disease
(N = 1325)
AML patients with CNS disease
(N = 45)
P value
Median age (range) 63 (17-89) 60 (17-79) 0.09
Sex n (%)
 Male 732 (55) 22 (49) 0.4
 Female 593 (45) 23 (51)
Ethnicity, n (%)
 Caucasian 1,048 (98) 25 (2)
 Hispanic 117 (94) 7 (6)
 African American 100 (91) 10 (9)
 Asian 26 (90) 3 (10)
 Unknown/other 34 (100) 0 (0)
Laboratory values, median (range)
 Hemoglobin, g/dL 8.8 (3 to 15) 9.1 (3 to 15) 0.8
 Platelets, ×109/L 47 (2 to 787) 47 (12 to 202) 0.4
 White blood cell, ×109/L 4.9 (0.2 to 433) 6.5 (2 to 92) 0.6
 LDH median, IU/L 747 (200 to 20,701) 1165 (383 to 12,405) 0.02
 Albumin, g/dl 3.5 (0.7 to 5.3) 3.2 (1.9 to 4.9) 0.06
Percent bone marrow blasts, mean (s.d.) 24 (27) 36 (31) 0.01
Karyotype 0.1
 Normal karyotype 612 (97) 19 (3)
 Trisomy 8 98 (95) 5 (5)
 Inversion(16) 71 (97) 19 (3)
 11q23 abnormalities 66 (93) 5 (7)
 trisomy(8:21) 62 (95) 3 (5)
 Miscellaneous 418 (30) 10 (22)

s.d., standard deviation.