Table I. Baseline characteristics of the study population.
AML patients without CNS disease (N = 1325) |
AML patients with CNS disease (N = 45) |
P value | |
---|---|---|---|
Median age (range) | 63 (17-89) | 60 (17-79) | 0.09 |
Sex n (%) | |||
Male | 732 (55) | 22 (49) | 0.4 |
Female | 593 (45) | 23 (51) | |
Ethnicity, n (%) | |||
Caucasian | 1,048 (98) | 25 (2) | |
Hispanic | 117 (94) | 7 (6) | |
African American | 100 (91) | 10 (9) | |
Asian | 26 (90) | 3 (10) | |
Unknown/other | 34 (100) | 0 (0) | |
Laboratory values, median (range) | |||
Hemoglobin, g/dL | 8.8 (3 to 15) | 9.1 (3 to 15) | 0.8 |
Platelets, ×109/L | 47 (2 to 787) | 47 (12 to 202) | 0.4 |
White blood cell, ×109/L | 4.9 (0.2 to 433) | 6.5 (2 to 92) | 0.6 |
LDH median, IU/L | 747 (200 to 20,701) | 1165 (383 to 12,405) | 0.02 |
Albumin, g/dl | 3.5 (0.7 to 5.3) | 3.2 (1.9 to 4.9) | 0.06 |
Percent bone marrow blasts, mean (s.d.) | 24 (27) | 36 (31) | 0.01 |
Karyotype | 0.1 | ||
Normal karyotype | 612 (97) | 19 (3) | |
Trisomy 8 | 98 (95) | 5 (5) | |
Inversion(16) | 71 (97) | 19 (3) | |
11q23 abnormalities | 66 (93) | 5 (7) | |
trisomy(8:21) | 62 (95) | 3 (5) | |
Miscellaneous | 418 (30) | 10 (22) |
s.d., standard deviation.