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. 2015 Apr 25;6(5):351–362. doi: 10.1007/s13238-015-0163-3

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© The Author(s) 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Helix-20 in EBOV NP _core indicates an essential hydrophobic pocket. (A) Comparison of EBOV NP_core and NiV NP. Both structures are shown as surface and colored gray. EBOV NP_core Helix-20 and NiV P₅₀ are shown as cartoon, colored salmon red and cyan, respectively. (B) Formation of the hydrophobic pocket. Main chain is shown in cartoon and hydrophobic residues are shown in stick, colored in red by hydrophobicity. (C) Interaction of Helix-20 with hydrophobic pocket. Hydrophobic pocket are shown in surface, Helix-20 are displayed in ribbon and stick, colored in red by hydrophobicity. (D) Primary sequence alignment of members of the filoviridae family. Highly conserved residue in Helix-14, Helix-15, Helix-19, and Helix-20 are indicated by yellow arrow