Table 3.
SCT Conditioning and Outcome Data
| SCT Parameters | Primary Diagnosis at Time of SCT |
|||
|---|---|---|---|---|
| RT (n = 20) |
CLL (n = 52) |
|||
| No. | % | No. | % | |
| Donor | ||||
| Matched related | 7 | 35 | 28 | 54 |
| Matched unrelated | 11 | 55 | 23 | 44 |
| Haplo-identical | 2 | 10 | 1 | 2 |
| Stem-cell source | ||||
| Peripheral blood | 14 | 70 | 36 | 69 |
| Bone marrow | 6 | 30 | 11 | 21 |
| Cord blood | 0 | 5 | 10 | |
| Conditioning regimen | ||||
| Myeloablative | 6 | 30 | 14 | 27 |
| Nonmyeloablative | 14 | 70 | 38 | 73 |
| Engraftment | ||||
| Yes | 20 | 100 | 48 | 92 |
| No | 0 | 4 | 8 | |
| Acute GVHD | ||||
| Yes | 12 | 60 | 25 | 48 |
| No | 8 | 40 | 27 | 52 |
| Chronic GVHD | 11 | 51 | 24 | 46 |
| Limited | 3 | 27 | 4 | 17 |
| Extensive | 8 | 73 | 20 | 83 |
| Best donor/recipient chimerism | ||||
| Only recipient | 0 | 2 | 4 | |
| Mixed donor/recipient | 12 | 63 | 24 | 51 |
| Only donor | 7 | 37 | 21 | 45 |
| Post-transplantation response | ||||
| Response | 13 | 65 | 37 | 71 |
| CR | 7 | 54 | 18 | 49 |
| PR | 6 | 46 | 19 | 51 |
| No response | 7 | 35 | 15 | 29 |
Abbreviations: CLL, chronic lymphocytic leukemia; CR, complete response; GVHD, graft-versus-host disease; PR, partial response; RT, Richter's transformation; SCT, stem-cell transplantation.