Table 5.
Prognostic Factor | HR | 95% CI | P |
---|---|---|---|
Univariable analysis | |||
Age ≥ 5 v < 55 years | 1.6 | 0.88 to 3.0 | .12 |
At time of transplantation | |||
ECOG performance status | |||
0 | 1 | ||
1 | 1.6 | 0.78 to 3.43 | .19 |
2 to 3 | 4.37 | 1.5 to 12.5 | .006 |
Hemoglobin | 0.74 | 0.63 to 0.87 | < .001 |
Albumin | 0.54 | 0.39 to 0.75 | < .001 |
Bone marrow cellularity | 0.99 | 0.98 to 1.01 | .93 |
Diagnosis (RT v CLL) | 2.75 | 1.48 to 5.11 | .001 |
Complex cytogenetics | 0.59 | 0.25 to 1.39 | .23 |
del(17)/p53 mutated | 0.75 | 0.36 to 1.52 | .42 |
Conditioning regimen* | 0.71 | 0.37 to 1.38 | .31 |
After transplantation | |||
Acute GVHD | 0.55 | 0.30 to 0.99 | .049 |
Chronic GVHD | 0.57 | 0.32 to 1.01 | .055 |
Best chimerism response† | 0.54 | 0.28 to 1.01 | .055 |
Post-transplantation response‡ | 0.40 | 0.22 to 0.75 | .006 |
Multivariable analysis | |||
Hemoglobin | 0.76 | 0.64 to 0.90 | .002 |
RT at time of transplantation | 3.54 | 1.74 to 7.22 | < .001 |
Response§ | 0.35 | 0.17 to 0.71 | .004 |
Chronic GVHD | 0.53 | 0.28 to 1.00 | .05 |
Abbreviations: CLL, chronic lymphocytic leukemia; ECOG, Eastern Cooperative Oncology Group; GVHD, graft-versus-host disease; HR, hazard ratio; RT, Richter's transformation; SCT, stem-cell transplantation.
Myeloablative versus nonablative.
Complete donor versus mixed/autologous.
Response versus no response.
At post-transplantation assessment.