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. 2015 Apr 6;33(14):1557–1563. doi: 10.1200/JCO.2014.58.6750

Table 5.

Prognostic Factor Analysis for Patients With Primary Diagnosis of CLL for Whom Allogeneic SCT Failed

Prognostic Factor HR 95% CI P
Univariable analysis
    Age ≥ 5 v < 55 years 1.6 0.88 to 3.0 .12
    At time of transplantation
        ECOG performance status
            0 1
            1 1.6 0.78 to 3.43 .19
            2 to 3 4.37 1.5 to 12.5 .006
        Hemoglobin 0.74 0.63 to 0.87 < .001
        Albumin 0.54 0.39 to 0.75 < .001
        Bone marrow cellularity 0.99 0.98 to 1.01 .93
        Diagnosis (RT v CLL) 2.75 1.48 to 5.11 .001
        Complex cytogenetics 0.59 0.25 to 1.39 .23
        del(17)/p53 mutated 0.75 0.36 to 1.52 .42
        Conditioning regimen* 0.71 0.37 to 1.38 .31
    After transplantation
        Acute GVHD 0.55 0.30 to 0.99 .049
        Chronic GVHD 0.57 0.32 to 1.01 .055
        Best chimerism response 0.54 0.28 to 1.01 .055
        Post-transplantation response 0.40 0.22 to 0.75 .006
Multivariable analysis
    Hemoglobin 0.76 0.64 to 0.90 .002
    RT at time of transplantation 3.54 1.74 to 7.22 < .001
    Response§ 0.35 0.17 to 0.71 .004
    Chronic GVHD 0.53 0.28 to 1.00 .05

Abbreviations: CLL, chronic lymphocytic leukemia; ECOG, Eastern Cooperative Oncology Group; GVHD, graft-versus-host disease; HR, hazard ratio; RT, Richter's transformation; SCT, stem-cell transplantation.

*

Myeloablative versus nonablative.

Complete donor versus mixed/autologous.

Response versus no response.

§

At post-transplantation assessment.