Table A4.
Pearson Correlation Between Blood Biomarkers and Indices of Obstructive (FEV1/FVC), Restrictive (TLC), and Diffusion (DLCO) Abnormalities
| Variable | TGF-β1 | P | PDGF-A | P | PDGF-B | P | SP-A | P | SP-D | P |
|---|---|---|---|---|---|---|---|---|---|---|
| Cancer survivors and controls (n = 163) | ||||||||||
| FEV1/FVC | –0.07 | .35 | –0.02 | .83 | –0.05 | .56 | 0.09 | .23 | 0.03 | .71 |
| TLC | –0.16 | .04 | –0.09 | .24 | –0.07 | .35 | 0.03 | .73 | 0.03 | .67 |
| DLCOcorr | –0.16 | .04 | –0.07 | .38 | –0.08 | .30 | 0.11 | .18 | 0.08 | .32 |
| Cancer survivors (n = 121) | ||||||||||
| FEV1/FVC | –0.11 | .22 | –0.05 | .62 | –0.09 | .31 | 0.15 | .11 | 0.06 | .53 |
| TLC | –0.06 | .51 | –0.06 | .50 | 0.01 | .89 | –0.08 | .40 | –0.05 | .61 |
| DLCOcorr | –0.08 | .38 | 0.03 | .76 | 0.03 | .76 | 0.02 | .87 | 0.03 | .77 |
Abbreviations: DLCO, diffusing capacity of the lungs for carbon monoxide; DLCOcorr, DLCO corrected for hemoglobin content, age, and sex; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; PDGF-A/B, platelet-derived growth factor A/B; SP-A/D, surfactant proteins A and D; TGF-β1, tumor growth factor beta1; TLC, total lung capacity.