Table 6.
Correlation of IGF-IR Biomarkers With PSA Response Categories
| Biomarker Measure | PSA (ng/mL) |
P* | |||||
|---|---|---|---|---|---|---|---|
| ≤ 0.2 (n = 19) |
> 0.2 to ≤ 4.0 (n = 4) |
> 4.0 (n = 12) |
|||||
| Median | Range | Median | Range | Median | Range | ||
| C-peptide | 15 | 125.2 | 32 | 68.6 | 18 | 29.5 | .77 |
| IGFBP-I | 1,583 | 11,293.8 | 7,177 | 14,173.8 | 1,756 | 87,213.0 | .27 |
| IGFBP-III | 73,934 | 90,660.8 | 64,237 | 396,021.7 | 63,478 | 65,506.7 | .12 |
| IGF-I | 0.7 | 22.2 | 0.5 | 22.2 | 4 | 21.3 | .47 |
| IGF-II | 129 | 1,087.2 | 164 | 1,296.9 | 120 | 161.7 | .30 |
| GH | 50 | 337.6 | 34 | 45.7 | 117 | 818.6 | .06 |
| Insulin | 9 | 119.3 | 8 | 81.2 | 8 | 34.0 | .51 |
Abbreviations: BP, binding protein; GH, growth hormone; IGF, insulin-like growth factor; IGF-IR, insulin-like growth factor I receptor; PSA, prostate-specific antigen.
*
Two-sided Kruskal-Wallis test.