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. Author manuscript; available in PMC: 2015 Oct 30.
Published in final edited form as: Nature. 2015 Apr 22;520(7549):697–701. doi: 10.1038/nature14418

Extended Data Figure 9. Suppression of POLR2A selectively inhibits the POLR2Aloss tumour growth.

Extended Data Figure 9

a, Immunohistochemical staining of xenografted xhCRC tumours. HE: haematoxylin and eosin. b, c, Tumour weights of orthotopically implanted HCT116 (b) and xhCRC (c) tumours. n = 10 mice per group. Data are mean and s.d. d, e, Body weights (d) and liver enzymes (e) including alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase in peripheral blood. Data are mean and s.d. n = 5 mice.