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. Author manuscript; available in PMC: 2015 Oct 30.
Published in final edited form as: Nature. 2015 Apr 22;520(7549):697–701. doi: 10.1038/nature14418

Extended Data Figure 10. Suppression of POLR2A by Ama-HEA125 inhibits the growth of POLR2Aloss tumours.

Extended Data Figure 10

a, d, g Protein levels of POLR2A in HCT116 (a), SW480 (d), or SW837 (g) cells. These cell lines are POLR2A-neutral, POLR2A-loss, or POLR2A-restored. b–c, e–f, h–i, Representative bioluminescent images (b, e, h) and tumour growth curves (c, f, i) of orthotopic xenograft tumours derived from the corresponding cells as indicated. All of them received dual intraperitoneal injections of anti-EpCAM antibody (3.6 mg kg−1) or Ama-HEA125 antibody-drug conjugate (10 and 90 μg kg−1, corresponding to 0.4 and 3.6 mg IgG kg−1). n = 10 mice per group. Error bars, s.e.m.