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. Author manuscript; available in PMC: 2015 Oct 30.
Published in final edited form as: Nature. 2015 Apr 22;520(7549):697–701. doi: 10.1038/nature14418

Figure 3. The sensitivity of POLR2Aloss cells to POLR2A inhibition is independent of p53.

Figure 3

a, Protein levels of POLR2A, p53 and EpCAM in a panel of isogenic human xhCRC cell lines. b, Cell proliferation of isogenic xhCRC cells treated with α-Amanitin. c, Sensitivity of isogenic xhCRC cells to 5-FU, Oxaliplatin (Oxa) or SN-38 treatment combined with or without α-Amanitin. d, Cell proliferation of isogenic xhCRC cells treated with Ama-HEA125. Data are mean and s.d. of three independent experiments in the figure.