Figure 2.
Consistent de novo mutation burden across affected hemispheres. (a) HME-1573 sampled during surgery in left orbital (Orb), frontal (Fr), central operculum (Co) and occipital (Occ) regions. (b) HME-1656 sampled in parietal (Par), central operculum and temporal (Tem) regions. (c) HME-1563 was sampled multiple independent times in the central operculum region (yellow circles), but samples could not be precisely aligned anatomically. Left, MRI scans; circles indicate brain areas examined by mass spectrometry analysis. Right, each sample aliquot was analyzed by mass spectrometry for mutation burden, describing variation in mutation burden across anatomical locations.