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. 2015 Mar 27;7(4):1030–1047. doi: 10.3390/toxins7041030

Figure 2.

Figure 2

Effects of OA, DTX-1 and YTX on human èter-a-go-go gene (hERG) channel activity. Automated patch clamp experiments were performed using a CHO cell line stably expressing hERG. (A) Voltage clamp protocol for the activation of hERG; (B) Representative current trace obtained after YTX addition. Currents were monitored for 5 min after toxin addition. COI: current of interest; (C) No effect of OA on hERG currents. Current magnitude is expressed as percentage of pre-treatment current that remained after 5 min of exposure to 10 µM OA or carrier alone (mean ± SEM; n = 4); (D) No effect of YTX on hERG currents. Current magnitude is expressed as percentage of pre-treatment current that remained after 5 min of exposure to 10 µM YTX or carrier (mean ± SEM; n = 4).