Figure 4.

Ultrastructural analyses of WT and Tg neocortex. (a) WT neocortical neurons from 3-, 6-, and 9-month-old animals. Regular ultrastructural features of the nuclear compartment (N) and cytoplasmic organelles (m, mitochondrion; er, endoplasmic reticulum; g, Golgi complex) are observed at all ages. (b) Tg neocortical neurons showing progressive damage, starting from 6 months of age. Mitochondrial (m) abnormalities include outer and inner membrane derangement, with disrupted cristae and vacuolization. Abnormally dilated Golgi complex (g), cisternae fragmentation (arrowheads), and numerous dense bodies (arrows) are also readily identified in 9-month-old Tg neocortical neurons.