Figure 8.

GPX1 expression and distribution in WT and Tg neocortex. GPX1 shows a strongly age- and genotype-related IHC pattern (a) consistent with WB densitometric data (b). Higher expression levels at 9 months and lower levels at 3 and 18 months are detected in Tg neocortex, as compared to WT. Values are expressed as mean ± SD. ^∗ P < 0.05; ^∗∗ P < 0.01; ^∗∗∗ P < 0.001. The higher magnification micrograph (c) shows elevated immunoreactivity in glial cells surrounding and infiltrating an amyloid plaque of 18-month-old Tg neocortex. Scale bars, 40 μm.