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. 2015 Apr 20;2015:967203. doi: 10.1155/2015/967203

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Copyright © 2015 Sara Porcellotti et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Peroxisomal protein levels and distribution in the neocortex of WT and Tg mice. PMP70 expression showing downregulation at 6 months, as assessed by WB densitometry (a) and IHC distribution (b). Enhancement of PMP70 expression is observed in 9-month-old Tg neurons. Scale bars, 40 μm. (c) Densitometric analyses of WB for CAT, Pex14p, AOX, and THL performed on neocortical protein extracts from 3-, 6-, 9-, 12-, and 18-month-old mice. Significant downregulation of CAT in 6-month-old Tg neocortex is detected. Values are expressed as mean ± SD. ^∗ P < 0.05; ^∗∗ P < 0.01; ^∗∗∗ P < 0.001.