Table 3. Impact of ethnicity and red blood cell variants on P. falciparum density.
cyfu | No. events | Median parasites/μL (IQR) | p-value* | p-value** | |
---|---|---|---|---|---|
Total | 2655.7 | 4091 | 14700(3850, 30100) | NA | NA |
| |||||
Ethnicity | |||||
Malinke | 2306.4 | 3474 | 14900(3900, 30600) | REF | REF |
Fulani | 206.2 | 344 | 13275(3000, 27650) | 0.2164 | 0.0769 |
Bambara | 92.0 | 201 | 14700(5300, 29950) | 0.1426 | 0.1395 |
Sarakole | 44.6 | 45 | 16025(3375, 24950) | 0.3091 | 0.2429 |
Dogon | 6.4 | 27 | 8550(1900, 18700) | 0.1911 | 0.1943 |
| |||||
Sex | |||||
Girls | 1303.5 | 2057 | 14100(3900, 29475) | REF | NA |
Boys | 1352.2 | 2034 | 15000(3800, 31000) | 0.9419 | NA |
| |||||
β-globin variant | |||||
HbAA | 2092.2 | 3343 | 15150(4250, 31050) | REF | REF |
HbAS | 378.0 | 408 | 10550(1350, 26250) | 0.0004 | 0.0004 |
HbAC | 167.8 | 321 | 13950(5100, 27050) | 0.6759 | 0.7757 |
HbSC | 14.0 | 12 | 750(75, 1700) | 0.1126 | 0.1029 |
HbCC | 2.2 | 4 | 5100(425, 6300) | 0.3165 | 0.3154 |
HbSS | 1.5 | 3 | 22125(100, 22125) | 0.3154 | 0.3150 |
| |||||
α-globin variant | |||||
Normal (αα/αα) | 1904.1 | 2876 | 14250(3800, 29900) | REF | REF |
α+ trait (-α3.7/αα) | 699.9 | 1127 | 15675(4050, 30550) | 0.7769 | 0.7273 |
α0 trait (-α3.7/-α3.7) | 51.7 | 88 | 12775(3950, 26850) | 0.6932 | 0.6874 |
| |||||
ABO blood group | |||||
A | 804.2 | 1266 | 14400(3900, 28125) | REF | REF |
B | 574.8 | 936 | 14250(3100, 32325) | 0.8027 | 0.7580 |
AB | 198.1 | 327 | 15750(4650, 32450) | 0.1503 | 0.1843 |
O | 1078.6 | 1562 | 14915(4175, 29975) | 0.5881 | 0.9525 |
| |||||
G6PD A- genotype | |||||
Boys | |||||
Normal | 1226.0 | 1837 | 15000(3725, 30600) | REF | REF |
A- hemizygotes | 126.2 | 197 | 15100(4350, 33075) | 0.5188 | 0.4440 |
Girls | |||||
Normal | 1044.3 | 1621 | 14025(3900, 28950) | REF | REF |
A- heterozygotes | 235.6 | 419 | 14750(3900, 30600) | 0.6897 | 0.8397 |
A- homozygotes | 23.6 | 17 | 10950(450, 36650) | 0.1091 | 0.1843 |
REF, reference group.
Adjusted for age only (bivariate analyses)
Adjusted from multivariate analyses that included age, ethnicity, β-globin and α-globin variants, ABO blood group, and G6PD A- genotype