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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Lancet Haematol. 2015 Apr 1;2(4):e140–e149. doi: 10.1016/S2352-3026(15)00043-5

Table 3. Impact of ethnicity and red blood cell variants on P. falciparum density.

cyfu No. events Median parasites/μL (IQR) p-value* p-value**
Total 2655.7 4091 14700(3850, 30100) NA NA

Ethnicity
Malinke 2306.4 3474 14900(3900, 30600) REF REF
 Fulani 206.2 344 13275(3000, 27650) 0.2164 0.0769
 Bambara 92.0 201 14700(5300, 29950) 0.1426 0.1395
Sarakole 44.6 45 16025(3375, 24950) 0.3091 0.2429
 Dogon 6.4 27 8550(1900, 18700) 0.1911 0.1943

Sex
 Girls 1303.5 2057 14100(3900, 29475) REF NA
 Boys 1352.2 2034 15000(3800, 31000) 0.9419 NA

β-globin variant
 HbAA 2092.2 3343 15150(4250, 31050) REF REF
 HbAS 378.0 408 10550(1350, 26250) 0.0004 0.0004
HbAC 167.8 321 13950(5100, 27050) 0.6759 0.7757
HbSC 14.0 12 750(75, 1700) 0.1126 0.1029
HbCC 2.2 4 5100(425, 6300) 0.3165 0.3154
HbSS 1.5 3 22125(100, 22125) 0.3154 0.3150

α-globin variant
 Normal (αα/αα) 1904.1 2876 14250(3800, 29900) REF REF
 α+ trait (-α3.7/αα) 699.9 1127 15675(4050, 30550) 0.7769 0.7273
 α0 trait (-α3.7/-α3.7) 51.7 88 12775(3950, 26850) 0.6932 0.6874

ABO blood group
 A 804.2 1266 14400(3900, 28125) REF REF
 B 574.8 936 14250(3100, 32325) 0.8027 0.7580
 AB 198.1 327 15750(4650, 32450) 0.1503 0.1843
 O 1078.6 1562 14915(4175, 29975) 0.5881 0.9525

G6PD A- genotype
Boys
 Normal 1226.0 1837 15000(3725, 30600) REF REF
 A- hemizygotes 126.2 197 15100(4350, 33075) 0.5188 0.4440
Girls
 Normal 1044.3 1621 14025(3900, 28950) REF REF
 A- heterozygotes 235.6 419 14750(3900, 30600) 0.6897 0.8397
 A- homozygotes 23.6 17 10950(450, 36650) 0.1091 0.1843

REF, reference group.

*

Adjusted for age only (bivariate analyses)

**

Adjusted from multivariate analyses that included age, ethnicity, β-globin and α-globin variants, ABO blood group, and G6PD A- genotype