Table 1. Demographics and variables analyzed for postoperative venous thromboembolism within 30 days of hysterectomy.
| Variable | Postoperative Venous Thromboembolism | P value | |
|---|---|---|---|
|
| |||
| No (N=20,386) | Yes (N=110) | ||
| Age, years | 46.9 (41.0, 55.0)49.0 ± 11.7 | 51.9 (44.6, 63.9)54.3 ± 13.6 | <0.001 |
| Parityy, median (IQR)* | 2 (1,3) | 2 (1,3) | 0.69 |
| Race | 0.002 | ||
| White | 71.9 (14,662) | 62.7 (69) | |
| Black | 17.8 (3,638) | 32.7 (36) | |
| Other/Unknown | 10.3 (2,086) | 4.6 (5) | |
| Body Mass Index, kg/m2 | 30.7 ± 8.129.3 (25.0, 35.0) | 34.6 ± 9.032.3 (27.5, 40.8) | <0.001 |
| Indication Cancer* | 9.6 (937/9,790) | 16.4 (18) | <0.001 |
| Obstetric Indication* | 0.2 (16/9,790) | 0 (0/47) | 1.00 |
| Current Smoker | 22.7 (4,632) | 10.9 (12) | 0.003 |
| Hypertension | 31.1 (6,343) | 49.1 (54) | <0.001 |
| Cancer | 0.6 (114/20,352) | 4.6 (5/109) | <0.001 |
| Diabetes: | |||
| Non-Insulin Dependent | 7.4 (1466/19,903) | 12.3 (13/106) | 0.06 |
| Insulin Dependent | 2.6 (483/18,920) | 4.1 (4/97) | 0.32 |
| Chronic Obstructive Pulmonary Disease* | 3.3 (463/14,187) | 7.2 (5/69) | 0.76 |
| Congestive Heart Failure | 0.1 (20/20,386) | 0 (0) | 1.00 |
| Coronary Artery Disease* | 2.7 (385/14,187) | 2.9 (2/69) | 0.71 |
| Dialysis | 0.09 (18/20,386) | 0.9 (1/110) | 0.10 |
| Thrombophilia | 1.1 (231/20,386) | 5.5 (6/110) | 0.002 |
| History of Venous Thromboembolism* | 2.9 (414/14,220) | 8.7 (6/69) | 0.02 |
| American Society of Anesthesiology Classification > 3 | 0.7 (134) | 3.6 (4) | 0.01 |
| Preoperative Thromboprophylaxis*: | |||
| Mechanical†* | 98.2 (13,945/14,194) | 98.6 (68/69) | 0.85 |
| Heparin‡† | 15.2 (21,60/14,194) | 31.9 (22/69) | <0.001 |
| Dual§‡ | 14.9 (2,116/14,194) | 31.9 (22/69) | <0.001 |
| None | 1.4 (1,97/14,194) | 1.4 (1/69) | 0.62 |
| Postoperative Thromboprophylaxis*: | |||
| Mechanical†* | 94.9 (11,584/12,205) | 97.1 (66/68) | 0.42 |
| Heparin‡† | 33.5 (4,086/12,203) | 55.9 (38/68) | <0.001 |
| Dual§‡ | 32.3 (3,940/12,203) | 55.9 (38/68) | <0.001 |
| None | 3.1 (381/12,203) | 1.5 (1/68) | 0.73 |
| Route of Hysterectomy | <0.001 | ||
| Abdominal | 29.9 (6,101) | 61.8 (68) | |
| Laparoscopic | 57.6 (11,744) | 34.6 (38) | |
| Vaginal | 12.5 (2,541) | 3.6 (4) | |
| Estimated Blood Loss (mL) | 184.3 ± 271.9100 (50, 200) | 389.9 ± 427.5250 (100, 500) | <0.001 |
| Urine Output (mL) | 182.0 ± 269.2200 (100, 391) | 361.2 ± 406.8220 (120, 400) | 0.65<0.001 |
| Postoperative Admission to Intensive Care Unit | 2.2 (263/12,169) | 23.5 (16/68) | <0.001 |
| Surgical Time (hours) | 2.3 ± 1.12.0 (1.5, 2.8) | 3.1 ± 1.52.9 (2.1, 3.8) | <0.001 |
Data presented as median (interquartile range), mean ± SD, % (n), , or % (n/N) unless otherwise specified. Chi-square and Fisher's Exact used for categorical variables, , Wilcoxon-Mann-Whitney test Student's t-test used for continuous variables.
*
Variable collected starting July 3, 2012 (N=16,548)
†
Sequential Compression Devices Includes both unfractionated or low-molecular weight heparin
‡
Includes both unfractionated or low-molecular weight heparinPatient received both sequential compression devices and either unfractionated or low-molecular weight heparin
§
Patient received both sequential compression devices and either unfractionated or low-molecular weight heparin