Table 6.
Outcomes of severe malaria cases a
| All severe cases no./no. (%) | IV-Artesunate no./no. (%) | IV-Quinine no./no. (%) | P value | ||||
|---|---|---|---|---|---|---|---|
| Hospitalization, days, median (range) (n=133) | 4 | (0–28) | 4 | (0–28) | 4 | (0–27) | 0.070 |
| Intensive care unit stay, days, median (range) (n=134) | 1 | (0–19) | 0 | (0–17) | 3 | (0–19) | 0.045 |
| Negative blood smear, days, median (range) (n=104) | 3 | (0–21) | 2 | (0–8) | 4 | (1–21) | 0.000 |
| Stepdown therapy | 130/150 | (87) | 88/99 | (89) | 42/51 | (82) | 0.265 |
| IV adverse events | 15/131 | (11) | 7/89 | (8) | 8/42 | (19) | 0.061 |
| Minor complication | 5/131 | (4) | 2/89 | (2) | 3/42 | (7) | 0.327 |
| Serious complication | 4/131 | (3) | 3/89 | (3) | 1/42 | (2) | 1.000 |
| Other complication | 6/131 | (5) | 2/89 | (2) | 4/42 | (10) | 0.083 |
| Outcome | |||||||
| Still hospitalized | 27/143 | (18) | 16/92 | (17) | 11/51 | (22) | 0.514 |
| Discharged | 100/143 | (70) | 64/92 | (70) | 36/51 | (71) | 0.898 |
| Deceased | 3/143 | (2) | 1/92 | (1) | 2/51 | (4) | 0.257 |
aThree cases were started on IV quinine and transferred to IV artesunate. To simplify analysis, those cases were classified as having received IV artesunate therapy alone. None had adverse events or negative outcomes.