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. 2015 Apr 30;16:103. doi: 10.1186/s12891-015-0555-9

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© Martini et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Bona fide EPC labelling in synovial tissue of JIA patients. A representative confocal imaging analysis of synovial tissue from a JIA patient (upper lane) and from a child who underwent surgical debridement for a non-inflammatory condition (lower lane). The staining for CD34 and VEGFR-2 (KDR) shows double positive CD34⁺KDR⁺ cells (bona fide EPCs) in clusters or as isolated cells only in the JIA case, while the control was completely negative. Note that, as expected, CD34 also labels microvessels, although at lower intensity compared to isolated EPCs.