Table 3.
Ordinal susceptibility scores for antimicrobial-organism pairs included in the spectrum score
| Anti-MRSA* | βL- Inhibitors** | Carbapenems & aztreonam*** | Cephalosporins**** | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Vanc | Lzld | Tig | Dapto | Ceftar | Pip/Taz | Tic/Clav | Amino-BLI | PSA Carb | Erta | Aztr | 1st Gen Ceph | 2nd Gen Ceph | 3rd Gen Ceph | PSA Ceph | |
| Gram positive organisms | |||||||||||||||
| Staphylococcus aureus | 4Ϯ | 4Ϯ | 4Ϯ | 4Ϯ | 4κ | 2¥ | 2¥ | 2¥ | 2¥ | 2¥ | 0I | 2¥ | 2¥ | 2¥ | 2¥ |
| Streptococcus pneumoniae | 4Ϯ | 4Ϯ | 4κ | 0Ψ | 4κ | 3¥ | 3¥ | 3¥ | 4Ϯ | 4Ϯ | 0I | 3Ϯ | 3Ϯ | 4Ϯ | 4Ϯ |
| Enterococcus faecalis | 4Ϯ | 4Ϯ | 4Ϯ | 4Ϯ | 0¥ | 4Ϯ | 4κ | 4Ϯ | 4Ϯ | 0κ | 0I | 0¥ | 0¥ | 0¥ | 0¥ |
| Enterococcus faecium | 4Ϯ | 4Ϯ | 4Ϯ | 4Ϯ | 0¥ | 1Ϯ | 1κ | 1Ϯ | 0Ϯ | 0κ | 0I | 0¥ | 0¥ | 0¥ | 0¥ |
| Gram negative organisms | |||||||||||||||
| Escherichia coli | 0I | 0I | 4Ϯ | 0I | 4κ | 4Ϯ | 4Ϯ | 3Ϯ | 4Ϯ | 4Ϯ | 4Ϯ | 4Ϯ | 4Ϯ | 4Ϯ | 4Ϯ |
| Klebsiella spp. | 0I | 0I | 4Ϯ | 0I | 4κ | 4Ϯ | 4Ϯ | 4Ϯ | 4Ϯ | 4Ϯ | 4Ϯ | 4Ϯ | 4Ϯ | 4Ϯ | 4Ϯ |
| OtherEnterobacteriaceae | 0I | 0I | 3Ϯ | 0I | 3κ | 4Ϯ | 4Ϯ | 2Ϯ | 4Ϯ | 4Ϯ | 4Ϯ | 1Ϯ | 2Ϯ | 4Ϯ | 4Ϯ |
| Enterobacter spp. | 0I | 0I | 4Ϯ | 0I | 3κ | 4Ϯ | 3Ϯ | 0Ϯ | 4Ϯ | 4Ϯ | 4Ϯ | 0Ϯ | 1Ϯ | 4Ϯ | 4Ϯ |
| Citrobacter spp. | 0I | 0I | 4Ϯ | 0I | 4κ | 4Ϯ | 4Ϯ | 3Ϯ | 4Ϯ | 4Ϯ | 4Ϯ | 2Ϯ | 3Ϯ | 4Ϯ | 4Ϯ |
| Serratia spp. | 0I | 0I | 4Ϯ | 0I | 3κ | 4Ϯ | 4Ϯ | 0Ϯ | 4Ϯ | 4Ϯ | 4Ϯ | 0Ϯ | 0Ϯ | 4Ϯ | 4Ϯ |
| Morganella spp. | 0I | 0I | 2Ϯ | 0I | 3κ | 4Ϯ | 3Ϯ | 0Ϯ | 4Ϯ | 4Ϯ | 4Ϯ | 0Ϯ | 0Ϯ | 4Ϯ | 4Ϯ |
| Proteus spp. | 0I | 0I | 1Ϯ | 0I | 4κ | 4Ϯ | 4Ϯ | 4Ϯ | 4Ϯ | 4Ϯ | 4Ϯ | 4Ϯ | 4Ϯ | 4Ϯ | 4Ϯ |
| Providencia spp. | 0I | 0I | 2Ϯ | 0I | 0Ψ | 4Ϯ | 4Ϯ | 0 | 4Ϯ | 4Ϯ | 4Ϯ | 0Ϯ | 2Ϯ | 4Ϯ | 4Ϯ |
| Pseudomonas aeruginosa | 0I | 0I | 0I | 0I | 0I | 4Ϯ | 4Ϯ | 0I | 4Ϯ | 1Ϯ | 4Ϯ | 0I | 0I | 0Ϯ | 4Ϯ |
| Acinetobacter spp. | 0I | 0I | 4Ϯ | 0I | 0κ | 3Ϯ | 3Ϯ | 3Ϯ | 3Ϯ | 0κ | 0Ϯ | 0Ψ | 0Ψ | 1Ϯ | 3Ϯ |
| Stenotrophomonas spp. | 0I | 0I | 3Ϯ | 0I | 0κ | 3Ϯ | 2Ϯ | 0I | 0Ϯ | 0κ | 0Ϯ | 0Ψ | 0Ψ | 0Ϯ | 1Ϯ |
| Haemophilus influenzae | 0I | 0κ | 4κ | 0I | 4κ | 4¥ | 4Ψ | 4Ϯ | 4Ϯ | 4κ | 4κ | 3Ψ | 4Ϯ | 4Ϯ | 4Ϯ |
| Bacteroides spp. | 0I | 0κ | 4κ | 0I | 0I | 4Ϯ | 3Ω | 4Ϯ | 4Ϯ | 4¥ | 0I | 0I | 0I | 1Ϯ | 0I |
| Other organisms | |||||||||||||||
| Atypical organisms | 0I | 0κ | 4κ | 0I | 0I | 0I | 0I | 0I | 0I | 0I | 0I | 0I | 0I | 0I | 0I |
| Legionella spp. | 0I | 0κ | 4κ | 0I | 0I | 0I | 0I | 0I | 0I | 0I | 0I | 0I | 0I | 0I | 0I |
| Mycoplasma spp. | 0I | 0κ | 4κ | 0I | 0I | 0I | 0I | 0I | 0I | 0I | 0I | 0I | 0I | 0I | 0I |
| Penicillins***** | Miscellaneous****** | ||||||||||||||
| Amino PCN | Semi Synth PCN | PSAFQ | NON-PSAFQ | Amik | Gent or Tobra | Macro | Clinda | Tetra | TMP/SMX | Metro | Colistin | ||||
| Gram positive organisms | |||||||||||||||
| Staphylococcus aureus | 0Ϯ | 2Ϯ | 2Ϯ | 3Ϯ | 4Ϯ | 4Ϯ | 1Ϯ | 3Ϯ | 4Ϯ | 4Ϯ | 0I | 0κ | |||
| Streptococcus pneumoniae | 3Ϯ | 3¥ | 4Ϯ | 4Ϯ | 0κ | 0κ | 3Ϯ | 4Ϯ | 3Ϯ | 3Ϯ | 0I | 0κ | |||
| Enterococcus faecalis | 4Ϯ | 0κ | 3Ϯ | 3Ϯ | 0I | 0I | 0Ϯ | 0¥ | 1Ϯ | 0¥ | 0I | 0κ | |||
| Enterococcus faecium | 0Ϯ | 0κ | 0Ϯ | 0Ϯ | 0I | 0I | 0Ϯ | 0¥ | 1Ϯ | 0¥ | 0I | 0κ | |||
| Gram negative organisms | |||||||||||||||
| Escherichia coli | 2Ϯ | 0I | 3Ϯ | 3Ϯ | 4Ϯ | 4Ϯ | 0I | 0I | 3Ϯ | 3Ϯ | 0I | 4Ϯ | |||
| Klebsiella spp. | 0Ϯ | 0I | 4Ϯ | 4Ϯ | 4Ϯ | 4Ϯ | 0I | 0I | 4Ϯ | 4Ϯ | 0I | 4Ϯ | |||
| OtherEnterobacteriaceae | 1Ϯ | 0I | 3Ϯ | 3Ϯ | 4Ϯ | 4Ϯ | 0I | 0I | 2Ϯ | 4Ϯ | 0I | 2Ϯ | |||
| Enterobacter spp. | 0Ϯ | 0I | 4Ϯ | 4Ϯ | 4Ϯ | 4Ϯ | 0I | 0I | 4Ϯ | 4Ϯ | 0I | 4Ϯ | |||
| Citrobacter spp. | 0Ϯ | 0I | 4Ϯ | 4Ϯ | 4Ϯ | 4Ϯ | 0I | 0I | 4Ϯ | 4Ϯ | 0I | 4Ϯ | |||
| Serratia spp. | 0Ϯ | 0I | 4Ϯ | 4Ϯ | 4Ϯ | 4Ϯ | 0I | 0I | 0Ϯ | 4Ϯ | 0I | 3Ϯ | |||
| Morganella spp. | 0Ϯ | 0I | 3Ϯ | 2Ϯ | 4Ϯ | 4Ϯ | 0I | 0I | 1Ϯ | 3Ϯ | 0I | 1Ϯ | |||
| Proteus spp. | 3Ϯ | 0I | 3Ϯ | 3Ϯ | 4Ϯ | 4Ϯ | 0I | 0I | 0Ϯ | 3Ϯ | 0I | 0κ | |||
| Providencia spp. | 0Ϯ | 0I | 2Ϯ | 2Ϯ | 4Ϯ | 2Ϯ | 0I | 0I | 0Ϯ | 3Ϯ | 0I | 0Ψ | |||
| Pseudomonas aeruginosa | 0I | 0I | 3Ϯ | 1Ϯ | 4Ϯ | 4Ϯ | 0I | 0I | 0I | 0I | 0I | 4Ϯ | |||
| Acinetobacter spp. | 0Ϯ | 0I | 3Ϯ | 2Ϯ | 4Ϯ | 3Ϯ | 0I | 0I | 2Ϯ | 3Ϯ | 0I | 4Ϯ | |||
| Stenotrophomonas spp. | 0Ϯ | 0I | 4Ϯ | 2Ϯ | 2Ϯ | 1Ϯ | 0I | 0I | 3Ϯ | 4Ϯ | 0I | 4Ϯ | |||
| Haemophilus influenzae | 3¥ | 0I | 4Ϯ | 4Ϯ | 4κ | 4κ | 4Ϯ | 0Ψ | 4Ϯ | 3Ϯ | 0I | 4κ | |||
| Bacteroides spp. | 0Ϯ | 0I | 2κ | 2¥ | 0I | 0I | 0κ | 3Ϯ | 1κ | 0κ | 4Ϯ | 0I | |||
| Other organisms | |||||||||||||||
| Atypical organisms | 0I | 0I | 4κ | 4κ | 2κ | 2κ | 4κ | 0κ | 4κ | 2κ | 0I | 0I | |||
| Legionella spp. | 0I | 0I | 4κ | 4κ | 4κ | 0κ | 4κ | 0κ | 4κ | 4κ | 0I | 0I | |||
| Mycoplasma spp. | 0I | 0I | 4κ | 4κ | 0Ψ | 0Ψ | 4κ | 0κ | 4κ | 0κ | 0I | 0I | |||
Special Notations:
Ϯ VA susceptibility data.
I No intrinsic activity.
Ψ Investigator opinion.
Ω Limited VA susceptibility data.
¥ Expert rule.
Κ Literature based.
Abbreviations:
*Anti-MRSA: Vanc = vancomycin; Lzld = linezolid; Tig = tigecycline; Dapto = daptomycin, Ceftar = ceftaroline.
**βL- Inhibitors: Pip/Taz = piperacillin/tazobactam; Tic/Clav = ticarcillin/clavulanate; AminoBLI = ampicillin/sulbactam, amoxicillin/clavulanate.
***Carbapenems and Aztreonam: PSACarba = imipenem, meropenem, Erta = ertapenem, Aztr = aztreonam.
****Cephalosporins: 1st Gen Ceph. = cefazolin, cephalexin; 2nd Gen Ceph = cefuroxime; 3rd Gen Ceph = ceftriaxone, cefotaxime, cefpodoxime; PSACeph = cefepime, ceftazidime.
*****Penicllins: AminoPCN = ampicillin, amoxicillin, penicillin; SemiSynthPCN = oxacillin, nafcillin.
******Miscellaneous: PSAFQ = ciprofloxacin or levofloxacin; NONPSAFQ = moxifloxacin, gemifloxacin; Amik = Amikacin; Gent or Tobra = gentamicin, tobramycin; Macro = erythromycin, azithromycin, clarithromycin; Clinda = clindamycin; Tetra = tetracycline, doxycycline; TMP/SMX = trimethoprim/sulfamethoxazole; Metro = metronidazole; Colistin = colistin.