Table 1.
Acute oral toxicity of Menthe longifolia essential oil in rats
| Treatment (mg/kg) | D/T |
Effects
|
|
|---|---|---|---|
| Mortality latency (h) | Symptoms of toxicity | ||
| 10 | 0/3 | - | None |
| 100 | 0/3 | - | None |
| 140 | 0/3 | - | Ataxia, hypoactivity, labored respiration, recovery after 10±8 min. |
| 225 | 0/3 | - | Hypoactivity, ataxia, labored respiration, head tics, body tremor, flaccid paralysis, recumbencey, recovery after 58±9 min. |
| 370 | 1/3 | >24, <28 | Ataxia, hypoactivity, labored respiration, head tics, body tremor, convulsion, flaccid paralysis, recumbencey, unresponsive to writhing reflex test, recovery after 97±5 min. |
| 600 | 3/3 | >22, <28 | Ataxia, hypoactivity, labored respiration, body and head tremor, convulsion, paddling, flaccid paralysis, recumbencey, unresponsive to writhing reflex test |
| 1000 | 3/3 | >1, <3 | Ataxia, hypoactivity, labored respiration, body and head tremor, convulsion, paddling, flaccid paralysis, recumbencey, unresponsive to writhing reflex test. |