. 2015 Mar-Apr;5(2):128–137.

Table 2.

Preventive and curative effect of Menthe longifolia essential oil (MLEO) on diarrhea onset and the time course of diarrhea induced by castor oil in rats

Treatment	Dose (mg/kg)	Diarrhea onset (min)	n	Animals with diarrhea (%)
				1 h	2 h	3 h	4 h
Control	-	103.66±20.73	6	0	100	100	100
MLEO	80	>240 ^*	6	0	0 ^a	0 ^a	0 ^a
MLEO	20	170.33±7.33 ^*	6	0	0 ^a	50 ^a	0 ^a
Loperamide	3	>240 ^*	6	0	0 ^a	0 ^a	0 ^a

Diarrhea was induced by giving castor oil (2 mL/rat, p.o.).The incidence of diarrhea was checked every hour for 4 h after the castoroil administration. MLEO and Loperamide were given orally 60 min beforethe castor oil treatment. Values are expressed as Mean±S.E.M and the percentage of animal with diarrhea.

p< 0.05 vs vehicle control (ANOVA followed by Dunnett test)

p< 0.05 vs vehicle control (Chi-square test).