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. 2015 Mar-Apr;5(2):128–137.

Table 2.

Preventive and curative effect of Menthe longifolia essential oil (MLEO) on diarrhea onset and the time course of diarrhea induced by castor oil in rats

Treatment Dose (mg/kg) Diarrhea onset (min) n Animals with diarrhea (%)
1 h 2 h 3 h 4 h
Control - 103.66±20.73 6 0 100 100 100
MLEO 80 >240 * 6 0 0 a 0 a 0 a
MLEO 20 170.33±7.33 * 6 0 0 a 50 a 0 a
Loperamide 3 >240 * 6 0 0 a 0 a 0 a

Diarrhea was induced by giving castor oil (2 mL/rat, p.o.).The incidence of diarrhea was checked every hour for 4 h after the castoroil administration. MLEO and Loperamide were given orally 60 min beforethe castor oil treatment. Values are expressed as Mean±S.E.M and the percentage of animal with diarrhea.

*

p< 0.05 vs vehicle control (ANOVA followed by Dunnett test)

a

p< 0.05 vs vehicle control (Chi-square test).