Table 3.
Antidiarrheal activity of Menthe longifolia essential oil (MLEO) on the diarrhea parameters that induced by castor oil in rats
| Treatment (mg/kg) |
Time course of diarrhea
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 h | 2 h | 3 h | 4 h | |||||||||
| F.NO* | F.W* | D.S* | F.NO | F.W | D.S | F.NO | F.W | D.S | F.NO | F.W | D.S | |
| Vehicle control (Tween 2%) | 0.00 | 0.00 | 0.00 | 4.00±1.45 | 3.55±0.93 | 7.33±1.72 | 1.66±0.21 | 1.28±0.08 | 3.33±0.81 | 2.33±0.21 | 1.28±0.09 | 4.33±1.50 |
| MLEO (80) | 0.00 | 0.00 | 0.00 | 0.00 a | 0.00 a | 0.00 a | 0.00 a | 0.00 a | 0.00 a | 0.00 a | 0.00 a | 0.00 a |
| MLEO (20) | 0.00 | 0.00 | 0.00 | 0.00 a | 0.00 a | 0.00 a | 3.33±1.69 | 3.20±1.08 | 5.83±2.31 | 0.00 a | 0.00 a | 0.00 a |
| Loperamide (3) | 0.00 | 0.00 | 0.00 | 0.00 a | 0.00 a | 0.00 a | 0.00 a | 0.00 a | 0.00 a | 0.00 a | 0.00 | 0.00 a |
The following parameters were recorded at hourly intervals for a period of 4 hr, including:
Values are expressed as Mean±SEM (n=6).
*
Fecal numbers (F.NO), fecal weight (F.W), diarrhea score (D.S).
a
p<0.05 vs. vehicle control.