Table 2.
Main results of meta-analysis for EGF +61A/G polymorphism and HCC risk
| Subgroup | No.comparisons | Sample size (case/control) | GG vs. GA + AA | GG + GA vs. AA | GG vs. AA | GA vs. AA | \G vs. A | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | I2(%) | OR (95% CI) | I2(%) | OR (95% CI) | I2(%) | OR (95% CI) | I2(%) | OR (95% CI) | I2(%) | |||
| Overall | 16 | 2475/5381 | 1.48 (1.20-1.84)* | 69.3** | 1.53 (1.22-1.92)* | 53.5** | 1.96 (1.43-2.68)* | 65.2** | 1.22 (1.04-1.42)* | 19.7 | 1.38 (1.17-1.63)* | 75.4** |
| Racial descent | ||||||||||||
| Asian | 9 | 2018/3655 | 1.19 (1.06-1.34)* | 24.9 | 1.20 (1.01-1.43)* | 16.3 | 1.40 (1.14-1.71)* | 1.3 | 1.10 (0.92-1.33) | 23.5 | 1.15 (1.05-1.26)* | 4.6 |
| European | 2 | 62/438 | 2.10 (1.07-4.13)* | 12.6 | 1.62 (0.84-3.13) | 0.0 | 2.51 (1.11-5.71)* | 0.0 | 1.30 (0.64-2.63) | 0.0 | 1.59 (1.05-2.41)* | 0.0 |
| African | 2 | 153/165 | 6.33 (3.39-11.83)* | 46.8 | 3.69 (2.23-6.10)* | 0.0 | 9.34 (4.61-18.91)* | 19.4 | 2.11 (1.21-3.67)* | 0.0 | 3.60 (2.55-5.08)* | 57.6 |
| Mixed | 3 | 242/1123 | 1.55 (0.79-3.06) | 77.3** | 1.52 (1.08-2.16)* | 46.9 | 1.94 (0.87-4.33) | 73.1** | 1.37 (0.94-2.00) | 11.0 | 1.45 (0.93-2.26) | 77.1** |
| Study quality | ||||||||||||
| High quality | 9 | 1688/4339 | 1.22 (1.08-1.38)* | 21.0 | 1.26 (1.04-1.52)* | 0.0 | 1.36 (1.11-1.67)* | 0.0 | 1.16 (0.94-1.42) | 0.0 | 1.18 (1.08-1.29)* | 0.0 |
| Asian | 6 | 1487/3003 | 1.22 (1.07-1.38)* | 0.0 | 1.23 (0.99-1.54) | 8.5 | 1.34 (1.06-1.69)* | 0.0 | 1.13 (0.89-1.43) | 23.2 | 1.17 (1.06-1.29)* | 0.0 |
| Others | 3 | 201/1336 | 1.29 (0.65-2.58) | 69.0** | 1.32 (0.92-1.91) | 0.0 | 1.45 (0.94-2.23) | 37.6 | 1.25 (0.84-1.85) | 0.0 | 1.22 (0.98-1.52) | 50.0 |
| Low quality | 7 | 787/1042 | 2.28 (1.23-4.23)* | 82.7** | 1.90 (1.17-3.09)* | 74.3** | 3.06 (1.62-5.76)* | 72.9** | 1.45 (1.02-2.07)* | 44.1** | 1.74 (1.14-2.65)* | 87.1** |
| Asian | 3 | 531/652 | 1.31 (0.72-2.38) | 69.6** | 1.14 (0.86-1.51) | 49.3 | 1.59 (1.05-2.43)* | 32.8 | 1.07 (0.80-1.44) | 48.8 | 1.14 (0.85-1.53) | 60.5** |
| Others | 4 | 256/390 | 3.57 (1.94-6.60)* | 53.4** | 2.89 (1.98-4.20)* | 22.6 | 5.67 (3.52-9.14)* | 41.6 | 1.88 (1.25-2.82)* | 0.0 | 2.47 (1.61-3.80)* | 65.8** |
| Source of controls | ||||||||||||
| Population-based | 5 | 940/1451 | 1.04 (0.88-1.24) | 0.0 | 1.28 (0.99-1.67) | 0.0 | 1.26 (0.94-1.67) | 0.0 | 1.29 (0.98-1.71) | 0.0 | 1.09 (0.96-1.24) | 0.0 |
| Asian | 3 | 805/1017 | 1.07 (0.89-1.29) | 0.0 | 1.29 (0.94-1.77) | 9.1 | 1.32 (0.95-1.84) | 0.0 | 1.26 (0.90-1.76) | 40.1 | 1.10 (0.95-1.27) | 0.0 |
| Others | 2 | 135/434 | 0.87 (0.54-1.40) | 0.0 | 1.27 (0.79-2.02) | 0.0 | 1.07 (0.60-1.90) | 0.0 | 1.37 (0.83-2.25) | 0.0 | 1.04 (0.78-1.39) | 0.0 |
| Hospital-based | 15 | 2358/3930 | 1.59 (1.27-1.99)* | 67.3** | 1.57 (1.21-2.04)* | 58.5** | 2.10 (1.49-2.96)* | 66.6** | 1.18 (1.00-1.39) | 27.6 | 1.44 (1.21-1.72)* | 75.8** |
| Asian | 9 | 2018/2638 | 1.23 (1.09-1.39)* | 20.2 | 1.16 (0.97-1.40) | 26.7 | 1.38 (1.11-1.71)* | 22.6 | 1.06 (0.88-1.28) | 24.6 | 1.16 (1.06-1.27)* | 17.6 |
| Others | 6 | 340/1292 | 2.79 (1.72-4.53)* | 54.0** | 2.31 (1.70-3.14)* | 37.9 | 3.77 (2.07-6.88)* | 55.5** | 1.61 (1.16-2.25)* | 0.0 | 2.08 (1.44-2.98)* | 69.0** |
| Type of controls | ||||||||||||
| Healthy controls | 8 | 1153/1708 | 1.10 (0.94-1.29) | 34.3 | 1.40 (1.11-1.76)* | 7.8 | 1.44 (1.11-1.86)* | 31.7 | 1.35 (1.05-1.72)* | 0.0 | 1.18 (1.00-1.41) | 43.4** |
| Asian | 5 | 998/1254 | 1.11 (0.94-1.32) | 36.8 | 1.36 (1.04-1.79)* | 0.0 | 1.47 (1.09-1.97)* | 8.5 | 1.28 (0.96-1.71) | 0.0 | 1.14 (1.00-1.30)* | 4.2 |
| Others | 3 | 155/454 | 1.01 (0.65-1.57) | 51.2 | 1.95 (0.81-4.73) | 58.4** | 2.08 (0.59-7.31) | 65.1** | 1.54 (0.96-2.47) | 16.6 | 1.59 (0.77-3.29) | 75.5** |
| Patients with chronic liver diseases | 12 | 1395/2696 | 1.74 (1.29-2.36)* | 70.0** | 1.87 (1.30-2.67)* | 58.7** | 2.58 (1.60-4.16)* | 69.9** | 1.36 (1.09-1.70)* | 36.0 | 1.56 (1.23-1.99)* | 76.9** |
| Asian | 5 | 1055/1424 | 1.19 (1.01-1.40)* | 11.0 | 1.64 (0.95-2.84) | 61.7** | 1.77 (1.02-3.06)* | 59.1** | 1.53 (0.86-2.72) | 62.6** | 1.17 (1.03-1.32)* | 23.3 |
| Others | 7 | 340/1272 | 2.73 (1.74-4.28)* | 45.2** | 2.22 (1.64-3.01)* | 34.2 | 3.53 (2.01-6.20)* | 47.5** | 1.55 (1.12-2.16)* | 0.0 | 1.98 (1.41-2.79)* | 64.4** |
| Number of cases | ||||||||||||
| ≥100 | 10 | 2195/3868 | 1.27 (1.01-1.60)* | 72.6** | 1.44 (1.07-1.94)* | 66.1** | 1.66 (1.13-2.43)* | 71.8** | 1.24 (0.98-1.58) | 39.7** | 1.26 (1.03-1.53)* | 80.7** |
| Asian | 8 | 1945/3538 | 1.17 (1.04-1.32)* | 0.0 | 1.16 (0.97-1.40) | 16.6 | 1.34 (1.08-1.65)* | 0.0 | 1.09 (0.90-1.32) | 31.3 | 1.13 (1.04-1.24)* | 0.0 |
| Others | 2 | 250/330 | 2.50 (0.26-23.99) | 95.8** | 2.15 (0.63-7.34) | 90.5** | 3.27 (0.28-37.81) | 95.5** | 1.62 (1.08-2.44)* | 36.5 | 2.00 (0.48-8.32) | 96.9** |
| <100 | 6 | 280/1513 | 2.28 (1.68-3.10)* | 0.0 | 1.79 (1.31-2.45)* | 0.0 | 2.82 (1.93-4.13)* | 0.0 | 1.40 (1.00-1.96) | 0.0 | 1.74 (1.43-2.12)* | 0.0 |
| Asian | 1 | 73/117 | 2.62 (1.20-5.74)* | - | 1.63 (0.89-3.00) | - | 3.00 (1.27-7.10)* | - | 1.29 (0.67-2.49) | - | 1.70 (1.11-2.59)* | - |
| Others | 5 | 207/1396 | 2.22 (1.59-3.10)* | 0.0 | 1.85 (1.28-2.66)* | 0.0 | 2.78 (1.82-4.25)* | 0.0 | 1.44 (0.97-2.14) | 0.0 | 1.75 (1.41-2.18)* | 0.0 |
OR, odds ratio; 95% CI, 95% confidence interval.
*Significant results, P-value <0.05.
**Random effect estimate.