Table 4.

Significant mRNAs and miRNAs in each treatment group compared between adenoma and adenocarcinoma outcomes, FC >1.5, FDR <10%, bold underline indicates a potential genetic factor

	MC− Air	Mc+ MCA	MC− MWCNT	MCA+ MWCNT
mRNA	Upregulated:, zfp942, zfp709, thoc7, robol, pdcd4, gas6, ednrb, cldn3, birc6, adm, hla-a, 2410017I17Rik, 17415391, 17474676 Downregulated: stats, selp, rrml, rpsl9bpl, mfl66, pfkp, olfr750, kras, clec9a, A830052DllRik, 17203463, 17482738	Upregulated: usp9x, ptger4, map2kl, kctdl, chd8, spib,wdfy4, bri3bp, mll5, pdzd8, cd5, il7r, rasal3, chdl, slcl5a2, ighm, bcl6, ighg, ddxl7, cd300e, tmeml84b, eif4ebp2, fam105a, ighm Downregulated: defb46, snord116, vmnlrl21, vmnlr80, 4933409K07Rik, 17350691, olfr750, olfr749, gm5458, gm3002, gml0338, gml0413, gm3594, gm 10408, gm906, 17303135	Upregulated: topors, pparg, ifit2, sstyl, ckap2, ccdc54, gml3288, sly Downregulated: 17209147, gm20759, cacng2, sstr5, kdm3b, bcl10, idua, erp29, loxl3, igk, igkv6-23, vmnlrl29, gm21142, dkk4, clcn3	Upregulated: ascl1, olfr46, socs2, ssty1, sly, gm 13288, vwf, bcl10, lmtk2, 17326563, 17206165 Downregulated: stat3, rin3, 17284562, il6st, c6, myl9, akrla1l, mpl, ccl1 9, abcb4, pf4, chfr, chic2, kdr, A430089I19Rik, hscb, sbnol, gm3139, 0610030E20Rik, ppp4r2, vwf, igkv4-91, sirt2, rrml, snordl16, cdh5, cmip, scamp2, bcl2a1a
miRNA	Upregulated: miR-25-5p Downregulated: miR-130a-3p, miR-6349, miR-6370, miR-467a-5p, miR-374b-5p	Upregulated: miR-466g Downregulated: miR-425-3p, miR-130a-3p, miR-130b-3p, miR-145a-5p, miR-5132-5p, miR-345-5p, miR-211-3p, miR-3090-5p, miR-92a-2-5p,miR-3102-5p	Upregulated: miR-6239 Downregulated: miR-143-3p, miR-145a-5p, miR-3473a, miR-345-5p, miR199a-l, miR-680-1	Upregulated: miR-5119 Downregulated: miR-203-3p, miR-126-3p, miR-449a-5p, miR-3102-5p, miR-191