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. Author manuscript; available in PMC: 2015 Oct 30.
Published in final edited form as: Nature. 2015 Apr 30;520(7549):675–678. doi: 10.1038/nature14366

Figure 2. Within the BLA, photostimulation of NAc or CeM projectors causes positive and negative reinforcement, respectively.

Figure 2

a, After rabies virus injection into NAc or CeM, animals were tested using intracranial self-stimulation (ICSS) and real time place aversion (RTPA) assays. b, Representative traces of nose poke responses during ICSS. c, The relative number of active nose pokes was related to the experimental group (one-way ANOVA, F2,18=10.50, **P=0.0012), and was significantly increased by photostimuation of NAc projectors in comparison to controls (t16=4.00, **P<0.01). d, Representative locomotor trace from an animal receiving CeM projector photostimulation during RTPA. e, The percentage of time spent in the photostimulation-paired zone was related to the experimental group (one-way ANOVA F2,45=4.38, *P=0.019) and was significantly decreased by photostimulation of CeM projectors in comparison to controls (t43=2.25, *P<0.05). Results show mean and s.e.m.