Table 1.
Band intensities were quantified from Western blots and ratio of band intensity from radiation + drug was divided by DMSO + radiation. Higher values indicate that the extractability pNPM1 is enhanced upon treatment with drug.
| Compound | Ratio in A549 Cells (Compound+6Gy/DMSO+6Gy) 25 μM |
|---|---|
| DMSO | 1.00 |
| 1a | 1.53 |
| 1b | 1.96 |
| 1c | 1.58 |
| 1d | 1.86 |
| 1e | 1.48 |
| 1f | 1.74 |
| 1g | 1.16 |
| 1h | 1.97 |
| 1i | 1.63 |
| 1j | 1.97 |
| 1k | 1.05 |
| 1l | 1.68 |
| 1m | 1.23 |
| 1n | 1.78 with 2.5 μM drug |
| 1o | ND# |
| 1p | (1.22) |
| 1q | 1.16 |
| 1r | 1.54 |
| YTR107 | 1.51 |
#
ND – Not determined