Table 4.
Adjusted general estimating equation models for IL-6 and tumor necrosis factor-α and symptoms in idiopathic and heritable pulmonary arterial hypertension
| Estimate | SE | P Value | |
|---|---|---|---|
| IL-6 (per SD) | |||
| Bodily pain | −2.06 | 0.38 | <0.001 |
| Vitality (fatigue) | −2.26 | 0.27 | <0.001 |
| Mental health (anxiety/depression) | −2.85 | 0.98 | 0.004 |
| TNF-α (per SD) | |||
| Bodily pain | 1.67 | 1.61 | 0.30 |
| Vitality (fatigue) | 2.24 | 0.23 | <0.001 |
| Mental health (anxiety/depression) | 0.75 | 0.63 | 0.24 |
Definition of abbreviation: TNF-α = tumor necrosis factor-α.
Adjusted for age, sex, race, body mass index, functional class, 6-minute-walk distance, C-reactive protein, N-terminal pro–brain natriuretic peptide, and randomized pulmonary arterial hypertension treatment group.