Table 5.

Micr RNA model results investigating the relationship between the echocardiographic parameters ejection fraction and left atrial volume index

	miRNA	Models: R2 (95% CI)a (χ2 P-value)b
		No covariates	BNP	Age and gender	BNP, age, and gender
EFc	None	–	0.10 (0.02–0.18) (P < 0.001)	0.08 (0.01–0.15) (P < 0.001)	0.21 (0.11–0.30) (P < 0.001)
	miR-146a	0.05 (−0.01 to 0.11)	0.13 (0.04–0.21) (P < 0.001)	0.15 (0.06–0.24) (P < 0.001)	0.25 (0.15–0.35) (P < 0.001)
	miR-221	0.04 (−0.01 to 0.10)	0.11 (0.03–0.19) (P < 0.001)	0.17 (0.08–0.27) (P < 0.001)	0.25 (0.15–0.35) (P < 0.001)
	miR-328	0.04 (−0.01 to 0.09)	0.11 (0.03–0.18) (P < 0.001)	0.16 (0.07–0.26) (P < 0.001)	0.24 (0.14–0.34) (P < 0.001)
	miR-30c	0.01 (−0.02 to 0.04)	0.10 (0.02–0.18) (P < 0.001)	0.10 (0.02–0.17) (P < 0.001)	0.22 (0.12–0.31) (P < 0.001)
	miR-375	0.01 (−0.01 to 0.03)	0.11 (0.03–0.19) (P < 0.001)	0.09 (0.02–0.17) (P < 0.001)	0.22 (0.12–0.32) (P < 0.001)
LAVId	None	–	0.41 (0.30–0.52) (P < 0.001)	0.14 (0.05–0.23) (P < 0.001)	0.42 (0.31– 0.53) (P < 0.001)
	miR-146a	0.01 (−0.02–0.05)	0.41 (0.30–0.52) (P < 0.001)	0.15 (0.05–0.24) (P < 0.001)	0.42 (0.31–0.53) (P < 0.001)
	miR-221	0.04 (−0.02 to 0.10)	0.41 (0.30–0.53) (P < 0.001)	0.18 (0.08–0.28) (P < 0.001)	0.42 (0.31–0.53) (P < 0.001)
	miR-328	0.01 (−0.02 to 0.04)	0.41 (0.30–0.52) (P < 0.001)	0.16 (0.06–0.25) (P < 0.001)	0.42 (0.31–0.53) (P < 0.001)
	miR-30c	0.00 (−)	0.41 (0.30–0.52) (P < 0.001)	0.13 (0.04–0.22) (P < 0.001)	0.41 (0.30–0.52) (P < 0.001)
	miR-375	0.00 (−)	0.42 (0.30–0.53) (P < 0.001)	0.14 (0.04–0.23) (P < 0.001)	0.42 (0.31–0.53) (P < 0.001)

CI, confidence interval LAVI, left atrial volume index; miRNA, microRNA.

^a95% CI = R²d ± t_{(0.975, n-k-1)}SE. n = size of sample, k = number of predictors, Olkin–Finn method for estimating the SE.

^bχ² test for difference on residual sum of squares compared with no-covariate model.

^cLinear model with full sample, outcome = EF².

^dLinear model with full sample, outcome = log-transformed LAVI.