Table 2.
Findings in protocol biopsies at one yr after transplantation
| ABOi n = 20 | ABOc n = 60 | p-value | |
|---|---|---|---|
| Interstitial inflammation, i | |||
| i score > 0, n (%) | 5 (25) | 7 (12) | 0.58 |
| Mean i score ± SD | 0.3 ± 0.57 | 0.18 ± 0.54 | |
| Tubulitis, t | |||
| t score > 0, n (%) | 5 (25) | 11 (18) | 0.77 |
| Mean t score ± SD | 0.3 ± 0.57 | 0.23 ± 0.53 | |
| Glomerulitis, g | |||
| g score > 0, n (%) | 1 (5) | 4 (7) | 0.95 |
| Mean g score ± SD | 0.05 ± 0.22 | 0.07 ± 0.25 | |
| Capillaritis, ptc | |||
| ptc score > 0, n (%) | 0 | 4 (7) | NA |
| Mean ptc score ± SD | 0 | 0.08 ± 0.33 | |
| Interstitial fibrosis, ci/IF | |||
| ci score > 0, n (%) | 17 (85) | 31 (58) | 0.054 |
| Mean ci score ± SD | 1.0 ± 0.56 | 0.53 ± 0.54 | |
| Tubulus atrophy, ct/TA | |||
| ct score > 0, n (%) | 18 (90) | 42 (70) | 0.14 |
| Mean ct score ± SD | 1.1 ± 0.64 | 0.72 ± 0.49 | |
| Intima fibrosis, cv | |||
| Score > 0, n (%) | 7 (35) | 18 (30) | 0.82 |
| Mean score ± SD | 0.7 ± 1.13 | 0.47 ± 0.85 | |
| Arteriolar hyalinosis, ah | |||
| Score > 0, n (%) | 6 (30) | 14 (23) | 0.76 |
| Mean score ± SD | 0.35 ± 0.59 | 0.25 ± 0.47 | |
| Transplant glomerulopathy, cg | 0 | 0 | NA |
| C4d > 50%, n (%) | 15 (75) | 3 (5) | 0.002 |
| C4d > 10%, n (%) | 17 (85) | 3 (5) | |
| t + i > 0, n (%) | 6 (30) | 12 (20) | 0.42 |
| g + ptc > 0, n (%) | 1 (5) | 5 (8) | 0.64 |
| ci + ct + cv + ah > 1, n (%) | 17 (85) | 36 (60) | 0.24 |
| ci + ct (IFTA) > 1 | 16 (80) | 28 (47) | 0.085 |
| Subclinical rejection at one yr, n (%) | 6 (30) | 11 (18) | 0.33 |
| ABMR, n (%) | 1 (5) | 0 | |
| ABMR + borderline, mixed, n (%) | 0 | 4 (7) | |
| Banff IA, n (%) | 0 | 2 (3) | |
| Borderline, n (%) | 5 (25) | 5 (8) | |
ABOi, ABO incompatible; ABOc, ABO compatible; NA, not applicable; SD, standard deviation; C4d, complement component 4d; ABMR, antibody-mediated rejection.